The Afghan president has arrived in Pakistan for a visit that is likely to focus in part on the role Islamabad can play in negotiations with the Taliban to end the war in Afghanistan.
Pakistan has strong historical ties with the Taliban and is seen as a key player in potentially pushing the militant group to strike a deal with the Afghan government.
But there is significant distrust between the two neighboring countries.
Hamid Karzai's visit Friday is his first since the U.S. raid that killed Osama bin Laden in the Pakistani army town of Abbottabad on May 2.
Karzai has said the operation highlighted that the war against terrorism should focus on Pakistan, not Afghanistan.
The U.S. has also pushed Pakistan to play a productive role in Taliban reconciliation.