Rep. Barney Frank's decision to step down at the end of his term is the latest jolt to the bruised ego of the Massachusetts Democratic Party, which once counted Kennedys, House speakers and a president among its ranks.
Instead, some of the state's best-known political figures are now Republicans, among them Sen. Scott Brown and presidential candidate Mitt Romney.
"For a long time, Massachusetts Democrats have felt they played a special role in the national Democratic Party," said Tufts University political science professor Jeffrey Berry. "I think that has gone at this point. There is no one in Congress from Massachusetts who has that stature now."
Frank has long been a liberal lightning rod and is the highest-profile member of the state's all-Democratic House delegation. His announcement follows the decision of another Massachusetts representative, John Olver, a member of the House Appropriations panel, not to seek re-election.
Add to those impending departures the death of Sen. Edward Kennedy in 2009 and the state's loss of a House seat in the most recent redistricting process, and some Democrats in Massachusetts are wondering whether the glory days are behind them.
While the state's senior senator, John Kerry, has a powerful perch as chairman of the Senate Foreign Relations Committee and often serves as a troubleshooter across the globe for the Obama administration, there's been plenty of speculation that if Obama wins re-election, Kerry could be tapped to succeed Secretary of State Hillary Rodham Clinton.
That would rob Massachusetts of a strong Senate presence.
Part of the decline is due to inexorable demographic changes that are working against the relatively small Northeastern state.
While Southern and Southwestern states have experienced population booms, Massachusetts has seen anemic growth, leading to the loss of one of its 10 seats in Congress.
The prospect of running in a newly redrawn district with 325,000 new constituents, combined with the Democrats' loss of control of the House, prompted Frank's decision not to run again after more than three decades in Congress, the 71-year-old said.
"One of the advantages to me of not running for office is that I don't even have to pretend to be nice to people I don't like," the famously acerbic Frank said.
There was a time not so long ago when Massachusetts Democrats held outsized political sway in Washington.
That power may have reached a high water mark during the country's post-World War II years. Massachusetts politicians held the powerful post of House speaker for nearly 20 years, first under John McCormack from 1962 to 1971 and then again under Thomas P. "Tip" O'Neill, who wielded the gavel from 1977 to 1987.
During that same span, another Massachusetts Democrat _ John F. Kennedy _ was elected president, and his brother Edward began what would be a nearly half-century of service in the Senate.
Even as the nation's population growth shifted away from the Northeast, Massachusetts Democrats still harbored big political dreams. Both Kerry and former Gov. Michael Dukakis won the Democratic nomination for president but lost in the general election.
One reason Massachusetts Democrats gained power in Washington is that they were able to easily win election again and again at home, giving them prized seniority on congressional committees, according to Berry.
Before Republicans won control of the House, Frank was chairman of the House Financial Services Committee and was key in crafting the Dodd-Frank bill, which contained the stiffest restrictions on banks and Wall Street since the Great Depression.
"That's the real loss, because committee chairs have enormous power to push projects and send money into various accounts that will help their home districts," Berry said.
Not everyone is ready to consign the state party's best days to the history books.
Massachusetts Democratic Party chairman John Walsh concedes the departure of Frank and Olver and the death of Kennedy are blows _ but are also part of the inevitable progression of politics.
He said the strength of the Massachusetts Democratic Party is the depth of its political farm league.
"We keep electing good strong, capable Democrats. We constantly have a stream of our leaders who are moving up the line," Walsh said. "I think Massachusetts has a place at the table not because of geography and not because of size, but because of the talent we have."
Walsh also pointed out the close political and personal relationship between Gov. Deval Patrick and President Barack Obama.
The immediate future of Massachusetts' reputation for political king-making may be in the hands of a Republican. While Romney is running for the GOP presidential nomination, he's been forced to play down his signature political accomplishment as Massachusetts governor _ passage of a landmark 2006 health care law.
Brown surprised many in the state by capturing the seat formerly held by Edward Kennedy in a special election last year after Kennedy's death from brain cancer. Democrats are pinning some of their hopes for the future on Harvard professor and consumer activist Elizabeth Warren, who has fired up the party's liberal base as she works to unseat Brown in next year's election.
Despite Frank's departure, the state still boasts some powerful Democrats with seniority and political muscle.
The dean of the delegation, Rep. Edward Markey of Malden, who was elected in 1976, is the ranking Democrat on the Natural Resources Committee and has been a leading party voice on climate change, nuclear safety, consumer issues and environmental matters.
Rep. Michael Capuano is a close ally of former House Speaker Nancy Pelosi and has emerged as a strong inside player on Capitol Hill.
Rep. Richard Neal of Springfield, a senior Democrat on the House Ways and Means Committee, is seen as a potential chairman of that powerful tax-writing panel. Rep. Jim McGovern of Worcester, meanwhile, is seen as a possible chairman of the House Rules Committee down the road.
Associated Press writers Andrew Miga in Washington and Bob Salsberg in Boston contributed to this report.