Along time ago, shortly after the big flood, I worked at a job which required me to undergo annual firearms re-qualification. It was a thoroughly enjoyable eight hour day filled with lectures, tests and lots of shooting. All of which brings me to make an observation about Michael3116's remarks.
His blanket statement regarding weapons choices for home defense leaves out one very important factor...the shooter. I started out the first three years of qualifications with a very nice 357 and my scores were adequate, but not impressive. Then I switched to a Colt Commander 45 and it was a whole new world. Suddenly I was scoring near the top consistently. Different guns fit different people differently.