What it means to be a conservative has changed. The GOP hasn't changed to match. So conservatives no longer support the GOP. Voters choose the Dems over the Dem-lites.
The difference is not as sharp on the local level. Voters know who they are voting for and can throw their support to conservative politicians. On the national level, the RNC and 'Rince and Dry' choose who to support. Voters make other choices. Until the GOP establishment dies off, there will be no more GOP Presidents.
The GOP cannot win without conservatives. Losing twice should have taught them that lesson. Inserting 'Rince and Dry' as chairman of the RNC proves they haven't learned anything from their last two defeats. That means a 3rd defeat is inevitable.