Give up on the Constitution? Why? What problem would that solve?
This question implicitly tells us what the liberal view of government is: it needs to overcome the will of the people. Our Constitution has within it the means to make any change necessary, through the amendment process. Any change really supported by the people will be made without difficulty.
Liberal/progressive/democrat supporters of "activist" juducial nominees are trying to thwart the will of a majority of their own contituents. Call them on it! There is no justification for working to overcome the mandates or limitations of the Constitution except an acknowledgement that they are trying to do something not supported by the people.