I think that Paul was commenting on the state of the population of the US. We have hit the tipping point. There are more voters that are Takers than Makers.
There is a lot of frustration at the state of the country and it is only going to get worse with more regulations and tax hikes.
The Makers will struggle to pull that wagon full of Takers but it is too much. There are too many.
So here we are. The Makers are frustrated and express it clumsily as secession. States can secede, not citizens.