Big business is naturally liberal because it is to their advantage to be liberal. Some leaders of big business may be conservative out of principle, but not out of self-interest. Businessmen may complain about regulation, but ultimately, most regulation helps big business: they can afford the lawyers and consultants to navigate the regulatory maze, while their small competitors cannot, and big businesses can afford to have lobbyists to steer regulations in directions that help them, or at least harm them less than their competition. The government often decides that a business is too big to be allowed to fail. You never see comparable bailouts for Fred's Donut Shop. Etc.