But ultimately, it was too late.
When the results were announced, late on Election Night, embryonic stem-cell research won in Missouri by the slimmest margins: 51 percent to 49 percent.
It wasn't early enough — but by Election Night, Missourians were finally waking up to the reality of what they were voting for.
In the end, the larger Democratic wave that swept Democrats into power in the House and likely the Senate — and McCaskill into the Missouri Senate seat — was simply too great a force to withstand.
In exit polls, support and opposition to the measure seemed to break down along similar lines to that of the political candidates.
One group that did not oppose the measure, in significant numbers, was Protestants, illustrating how even the most ardent pro-life voters were still being lured in by the measure's deceptive language.
Despite the loss, conservative activists learned several things.
Conservatives must get active earlier, as just a few extra days campaigning against the measure might have made the difference. They must also not give up fighting on the embryonic stem-cell research issue as it moves across the country.
This won't be the last time it's a voting issue, and when it appears on another state's ballot, conservatives must get to work early.
Support for this extreme and largely ineffective form of stem-cell research is not nearly as strong as first believed, and when voters are fully informed, they won't be fooled by tricky legalese and celebrity endorsements.
Missouri was a wake-up call and conservatives need to be ready next time.