If Democrats were forced to stage a real filibuster, which would be more difficult with a larger Republican majority, they would have to follow the fairly stringent rules for carrying on a filibuster. Conversely Republicans would be required to maintain a quorum to force the filibuster to continue indefinitely, lest the Democrats end debate and go home for a good night's rest. During the civil-rights debate, senators were seen in the Senate Chamber in bathrobes, and cots were set up in the cloakrooms. And, if the majority needed to maintain a quorum, they could summon the sergeant at arms to arrest senators who weren't present in the chamber.
Following a few days of a real forced filibuster, most Democrats would peel away from their irresponsible obstructionism one-by-one, and the public would see on the nightly news exactly who is really obstructing the business of the people, which would be particularly acute in the case of a Supreme Court nominee.
Therefore, Senate Republicans should forget procedural shenanigans, break out the cots and arrest a few senators, if necessary. There's no better way to show support for the president's nominees than to actually fight for them rather than staging an ersatz fight and letting them languish for years in political purgatory.