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“The assassination of Benazir Bhutto is a tragic event for Pakistan and for democracy in Pakistan. Her murderers must be brought to justice and Pakistan must continue the path back to democracy and the rule of law. Her death is a reminder that terrorism anywhere — whether in New York, London, Tel-Aviv or Rawalpindi — is an enemy of freedom. We must redouble our efforts to win the Terrorists’ War on Us.”

“I am deeply troubled by the news accounts this morning of Pakistani opposition leader and former Prime Minister Benazir Bhutto’s assassination in a suicide attack. This is devastating news for the people of Pakistan, and my prayers go out to them as we follow developments regarding this dire situation.

”The terrible violence surrounding Pakistan’s upcoming election stands in stark contrast to the peaceful transition of power that we embrace in our country through our Constitution. On this sad day, we are reminded that while our democracy has flaws, it stands as a shining beacon of hope for nations and people around the world who seek peace and opportunity through self-government.”

"We are still learning the details of today's tragic events in Pakistan, but this is a stark reminder that America must not only stay on high alert, but remain actively engaged across the globe. Pakistan has long been a key part in the war against extremism and radical jihadists. For those who think Iraq is the sole front in the War on Terror, one must look no further than what has happened today. America must show its commitment to stand with all moderate forces across the Islamic world and together face the defining challenge of our generation – the struggle against violent, radical jihadists.

"At this difficult time, our thoughts and prayers go to the family of Benazir Bhutto, and to all the people of Pakistan who are fighting against extremist forces that would commit such heinous acts as the whole world has witnessed today."

McCain, in a statement, said the death of Bhutto "underscores yet again the grave dangers we face in the world today and particularly in countries like Pakistan, where the forces of moderation are arrayed in a fierce battle against those who embrace violent Islamic extremism.

"Given Pakistan's strategic location, the international terrorist groups that operate from its soil, and its nuclear arsenal, the future of that country has deep implications for the security of the United States and its allies. America must stand on the right side of this ongoing struggle," he said, noting that he has made numerous visits to Pakistan.

"I am shocked and saddened by the death of Benazir Bhutto in this terrorist atrocity. She was a respected and resilient advocate for the democratic aspirations of the Pakistani people. We join with them in mourning her loss, and stand with them in their quest for democracy and against the terrorists who threaten the common security of the world."

"I am profoundly saddened and outraged by the assassination of Benazir Bhutto, a leader of tremendous political and personal courage. I came to know Mrs. Bhutto over many years, during her tenures as Prime Minister and during her years in exile. Mrs. Bhutto's concern for her country, and her family, propelled her to risk her life on behalf of the Pakistani people. She returned to Pakistan to fight for democracy despite threats and previous attempts on her life and now she has made the ultimate sacrifice. Her death is a tragedy for her country and a terrible reminder of the work that remains to bring peace, stability, and hope to regions of the globe too often paralyzed by fear, hatred, and violence.

"Let us pray that her legacy will be a brighter, more hopeful future for the people she loved and the country she served. My family and I extend our condolences and deepest sympathies to the victims and their families and to the people of Pakistan."