Calls to HBO seeking comment were not immediately returned.
Deal Hudson, author and publisher of InsideCatholic.com, said he doesn't find any humor in the episode.
"I don't think it's funny," Hudson told Foxnews.com. "Why is it that people are allowed to publicly show that level of disrespect for Christian symbols? If the same thing was done to a symbol of any other religions -- Jewish or Muslim -- there'd be a huge outcry. It's simply not a level playing field."
Hudson said an apology from the show's producers and writing team should be issued.
"Somebody should [apologize]," Hudson said. "When is it going to stop? When is common sense going to dictate that people realize this willingness of artists to do to Christianity what they would never do to Judaism or Islam?"
The episode, "The Bare Midriff," primarily revolves around David's assistant and her belly-revealing attire. According to the show's Web site, a "new pill" increased David's urine flow, leading to the "misunderstanding about a miraculously weeping Jesus."
HBO promoted the controversial scene on the show's site, complete with a "squirm-o-meter" that ranked the urine incident, ahead of David's confronting his assistant about her exposed midriff.